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This approach will also allow for proof of causation when a new gene is found to be associated with EDS and aid in the identification of new candidate genes for human EDS

Since this is an emerging issue, several types of studies have been included, not only human clinical trials, but also in vitro and animal studies, which has led to a great heterogeneity in the results and methods used, making synthesis difficult

doi: 10.1016/j.jsbmb.2018.04.008 21 CasperRFMitwallyMF

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Black skin: 1 capsule daily at least 2 years For all, the ideal doses are 10-20mg per kg of the body weight divided into two doses daily

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