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One study indicates that both copies of the autosomal tumor suppressor gene must be inactivated to form a tumor, and metabolite changes during aging play a significant role in this process [222]

246 However, p38MAPK inhibitors block the upstream MAPK kinase kinases, leading to hyperactivation of the transforming growth factor-activated kinase-1 and mixed-lineage kinase which then hyperactivate the JNK

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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Mubeen S, Zhang T, Chartuprayoon N, Rheem Y, Mulchandani A, Myung NV, Deshusses MA

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