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Abbreviations A -amyloid ACA Acetoacetate AD Alzheimers disease AhR Aryl hydrocarbon receptor AMPK AMP-activated protein kinase ARRB2 -arrestin-2 BBB Blood-brain barrier BDNF Brain-derived neurotrophic factor BMI Body mass index -HB -hydroxybutyrate CNS Central nervous system COMT Catecholamine O-methyl transferase COX-2 Cyclooxygenase-2 CRP C-reactive protein CSF Cerebrospinal fluid ENS Enteric nervous system FMT Fecal microbiota transplantation GDNF Glial cell line-derived neurotrophic factor GI Gastrointestinal GPR40 G proteincoupled receptor 40 HbA1c Glycated hemoglobin HCA2 Hydroxycarboxylic acid receptor 2 HDAC Histone deacetylase HDL High-density lipoprotein IBD Inflammatory bowel disease IGF Insulin growth factor IL-1 Interleukin-1 Il-6 Interleukin-6 KBs Ketone bodies KD Ketogenic diet LDL Low-density lipoprotein LGIT Low glycemic index treatment LPS Lipopolysaccharides MAD Modified Atkins diet MCTs Medium-chain triglycerides MCT-KD Medium-chain triglyceride ketogenic diet MDS-UPDRS Movement Disorder Society Unified Parkinsons Disease Rating Scale mGluR5 Metabotropic glutamate receptor 5 MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine NF-B Nuclear factor -light-chain-enhancer of activated B cells NFTs Neurofibrillary tangles NLRP NOD-like receptor protein NT-3 Neurotrophic protein 3 PAS Parkinsons anxiety scale PD Parkinsons disease PD-MCI Parkinsons disease with mild cognitive impairment PPAR Peroxisome proliferator-activated receptor RNS Reactive nitrogen species ROS Reactive oxygen species rsEEG Resting state electroencephalography SCFAs Short-chain fatty acids SIBO Small intestinal bacterial overgrowth TKD Targeted ketogenic diet TLR3 Toll-like receptor 3 TNF- Tumor necrosis factor Trp Tryptophan TUG Timed up and go test UCPs Uncoupling proteins VHI Voice handicap index VLCKD Very low-calorie ketogenic diet Author contributions All authors provided the overall concept and framework of the review

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