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After 14 days, the mice were sacrificed, and their major organs and tissues were analyzed with a hematoxylin and eosin (H&E) stain (Supplementary Fig

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Furthermore, the elucidation of the viral entry mechanism through mGluR2, due also to its predominant expression in brain tissues, unlike the recognised internalising receptor ACE2, may provide insights into the severe impact of COVID-19 on the brain and its intricate relationship with astrocyte damage, aberrant neuroinflammation, excitotoxicity, impairment of the glymphatic system as well as DLPFC and hippocampal injury [18, 233, 239]

LC-MS/MS was performed with a Waters Acquity UPLC system with Quattro Premier XE tandem mass spectrometer