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In inborn errors of metabolism, these rare congenital disorders like McArdle syndrome, Friedreichs ataxia

The importance of maintaining the metabolic health of the carnitine pool is emphasized by the high demand for carnitine in tissues that cannot synthesize carnitine, such as the myocardium and skeletal muscle

Finally, the relatively small effect size might not be of clinical significance

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doi:10.3389/fpsyt.2021.671151 13

Abstract Acetyl-L-carnitine (ALC) has shown a neuroprotective effect in patients with peripheral neuropathies of different etiologies