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Anti-inflammatory effects complement the regenerative mechanisms, with TB-500 reducing inflammatory cytokine expression and limiting excessive inflammation that can impair healing

Intriguingly, when older mice were given MOTS-c injections to restore their MOTS-c to more youthful levels, it reversed certain aging effects specifically, it restored insulin sensitivity in aged muscles and improved the animals exercise capacity to levels comparable with younger mice

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These optimistic clinical outcomes were validated in individuals with concurrent IBS-D, stress, and depression by a randomized controlled study (RCT) (262)