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Cancer-cell metabolism studies NNMT is overexpressed in several cancer cell lines, and 5-Amino-1MQ has been used in vitro to characterise its role in tumour metabolism

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For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors