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Insulin Resistance (with prolonged use) Paradoxically, while IGF-1 LR3 acutely improves glucose uptake, chronic high-dose use can promote insulin resistance as a compensatory mechanism

This model of MRP1, built long before the release of the Cryo-EM structure of human MRP1 40 , remains in adequacy with the published Cryo-EM structure, validating our choice of mutants

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