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Specifically, it has been reported that 4 weeks after intraperitoneal injection of urethane, Nrf2 / mice produce approximately sevenfold more microscopic nodules in their lungs than wild-type mice, and that 8 weeks after urethane treatment all lungs of Nrf2 / mice develop surface tumors, whereas only half of the wild-type lungs do so [182]

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This tightly regulated process begins with signal detection by microglia through pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), or other damage associated receptors, such as receptor for advanced glycation end products (RAGE) and scavenger receptors, prompting a transition from a surveillant to a reactive state (Kraft and Harry, 2011)