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Are there alternatives to the primary approach that you're suggesting

the manufacturers data claim a 50% deposition in the olfactory region [10]
Journal of Alzheimer's disease : JAD, 62(2), 561570

10.1038/s41569-020-0403-y 37 HuQ.WeiW.WuD.HuangF.LiM.LiW.et al (2022)
WDR49-positive astrocytes mark severity of neurodegeneration in frontotemporal lobar degeneration and Alzheimers disease

Baseline analysis before treatment establishes starting point
