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Fertility was normal in the offspring of rats exposed daily from before birth (in utero) through sexual maturity at daily exposures (AUC) of approximately 18 times higher than human exposures at the recommended 150 mg daily dose

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doi: 10.1111/j.1365-2036.2011.04938.x
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Microbiome 5 (1), 54

The medication must be protected from light exposure, as both active ingredients may be sensitive to light-induced degradation
