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Intranasal transplantation of human neural stem cells ameliorates Alzheimer's disease-like pathology in a mouse model
Gil Blander and Ashley Reaver, are joined by Dr
In iPSC-derived neurons, CRISPR/Cas9 correction of APOE4/4 to an APOE3/3 genotype reduces susceptibility to cytotoxicity, tau secretion, and tau phosphorylation [101]
Nevertheless, their dose-dependent toxicity, particularly thrombocytopenia and neutropenia, represents a significant barrier to their widespread use [193]
doi: 10.1016/j.jacc.2018.04.052
Biochimie 88 , 17071719 (2006)
