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2024;282(Pt 2):136695

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doi: 10.3389/fimmu.2026.1793865 Received 22 January 2026 Revised 11 April 2026 Accepted 21 April 2026 Published 05 May 2026 Volume 17 - 2026 Edited by Tabinda Hasan, Princess Nourah bint Abdulrahman University, Saudi Arabia Reviewed by Mudit Tyagi, Thomas Jefferson University, United States Weiting Liao, First Affiliated Hospital of Chongqing Medical University, China Updates Copyright 2026 Su, Tan, Zheng and Ding

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The current strategies for exploration encompass various avenues: botanical research (identifying and characterizing novel cannabinoids present in different cannabis strains), synthetic chemistry (chemical synthesis enables the creation of cannabinoid analogs with desired therapeutic properties), metabolic engineering (modifying the biosynthetic pathways of cannabis plants encourages the production of specific novel cannabinoids), selectivity to receptor subtypes (identifying cannabinoids with specific receptor selectivity holds promise for more targeted therapies with fewer side effects), non-psychoactive cannabinoids (exploring cannabinoids devoid of THCs psychoactive effects while retaining therapeutic benefits broadens their potential applications and addresses concerns about misuse), water-soluble formulations (developing water-soluble cannabinoid formulations enhances bioavailability and facilitates administration through various routes) [8,97]