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Statistical analysis All statistical analyses in this study were performed using GraphPad Prism software (version 9.0.0)

However, the immunosuppressive effects of the SASP impedes the immune clearance of senescent cells, leading to their accumulation with age and the pathogenesis of age-related diseases

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Conversely, MMP-3 overexpression reduces collagen I levels in AD-MSCs (Rong et al., 2020), and its downregulation promotes NP-MSC chondrogenic differentiation (Zhang Q

[DOI] [PubMed] [Google Scholar] 112.Ridderikhof M.L., Leenders N., Goddijn H., Schep N.W., Lirk P., Goslings J.C., Hollman M.W