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The oxygen-binding site on CIV is comprised of a binuclear heme iron/copper center, which exists in an oxidized or reduced state depending on the surrounding oxygen concentrations ( Although it has been established that NO decreases the flow of electrons through the respiratory chain complexes, which inhibits respiration and decreases oxygen consumption ( Alternatively, there is the notion that NO advantageously affects mitochondrial efficiency ( NO and redox state Not only does NO regulate mitochondrial function and biogenesis via interactions with signaling molecules and the electron transport chain, but it also regulates the production of mitochondrial free radicals (reactive oxygen species and reactive nitrogen species) (Figure 3)

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If the oxidative stress wins this battle, sperm quality is affected

[DOI] [PubMed] [Google Scholar] Cinosi EMartinotti GSimonato PSingh DDemetrovics ZRoman-Urrestarazu ABersani FSVicknasingam BPiazzon GLi J-H, et al