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found that ferroptosis-related genes were mainly expressed in tubular cells after IRI

This effect is specific to these three complex subunits, as deletion of other components of SAGA/SLIK have normal or shortened replicative lifespan (McCormick et al., 2014)

PMID: 28863392

Taking NAD+ and glutathione together creates a reinforcing cycle of cellular protection because NAD+ metabolism generates NADPH for glutathione recycling while glutathione protects against oxidative damage that depletes NAD+

Tramontin et al., 2019

However, in PD, -syn monomers undergo misfolding and aggregate into fibrous structures that transfer between neurons and rapidly spread throughout brain regions, causing functional damage and neuronal death (Park et al., 2025)