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A further illustration of this diversity in the genome comes from the Catalogue of Somatic Mutations in Cancer which lists 101 somatic mutations across the coding sections of NNMT, as a consequence changing or deleting 85 of the predominant amino acid residues (25)
This is also consistent with the fact that metformins primary beneficial effect in type 2 diabetes is in the intestines [30]
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Forsyth JC, Mueller PD, Becker ChE, Osterloh J, Benowitz NL, Rumack BH, Hall AH
[Epub ahead of print]
