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Overproduction of free radicals such as reactive oxygen species and reactive nitrogen species leads to oxidative stress, which is associated with the pathophysiology of various human diseases including cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases (Alzheimer disease and Parkinson disease), rheumatoid arthritis, and ageing

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Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin

Congruently, we found increased CD68 + macrophage infiltration in adipose tissue of obese compared with lean individuals confirming local fat inflammation, but they did not correlate with circulating MOTS-c levels, dissociating MOTS-c from local immune cell infiltration

It was then shown in VLDL turnover studies that the clearance of VLDL from the circulation was less efficient in apoC1 transgenic mice as compared with control mice

The rTMS-induced improvements in quality of life occur via the metabolism of the right limbic system, which may be the neural substrate of the rTMS effect on emotional dimensions [71]