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doi: 10.1021/acschemneuro.3c00739

Apart from the potent GH-releasing action, ghrelin has other actions including stimulation of lactotroph and corticotroph function, influence on the pituitary gonadal axis, stimulation of appetite, control of energy balance, influence on sleep and behavior, control of gastric motility and acid secretion, influence on exocrine and endocrine pancreatic function as well as on glucose metabolism, cardiovascular actions and modulation of proliferation of neoplastic cells, as well as of the immune system

For example, a study using vegan donor FMT for cirrhosis patients found it induced significant changes in gut flora (such as Eubacterium siraeum and Blautia wexlerae ) and plasma metabolites (such as phenylacetylcarnitine) and affected hepatic DNA methylation profiles, suggesting FMT may act through multi-omics-level meta-organism pathways

Thus, exploring how environmental and endogenous aldehydes might interact to accelerate disease or tissue injury processes represents an exciting area of future investigation

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In turn, O-GlcNAcylation regulates signaling pathways via PTMs in reaction to fluctuations in blood glucose levels