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It may be helpful in this regard to enhance the development of antioxidants that particularly target the mitochondrial compartment, either by scavenging ROS within these organelles, which are known to promote ROS formation by the mitochondrial electron transport chain (135, 136)

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Electrochemical Determination of Kynurenine Pathway Metabolites-Challenges and Perspectives

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Our data further suggest that autologous fibroblasts can induce native NP cells in degenerative IVDs to adopt a fibrotic phenotype via the activation of TGF/Smad signaling in order to enhance the reparative fibrosis and healing process (Fig

a Evidence grades are indicative and based on convergence between CPIC/DPWG, guideline status for CYP2C19/CYP2D6 and the broader pharmacogenetic literature for SLC6A4, HTR2A and ABCB1