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First, mutations at positions 14 and 17 stabilize the central helix through a salt bridge

However, systemic copper loading remains a theoretical concern requiring careful dose optimization and copper status monitoring, particularly with chronic administration protocols

Sustained Release: Topical formulations (creams, gels, patches) can be engineered to release their payload slowly over hours or days

Kanazawa I, Tanaka KI, Sugimoto T

Physical PROMs had lower stability, with consistently stable proportions ranging from 11.2% (right lower limb limitations) to 64.3% (limitations in driving)

4% at 10 time steps), suggesting greater homogeneity between countries (Fig