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Mediated by the TOM complex, PINK1 undergoes trans-autophosphorylation and subsequent conformational rearrangement, thereby activating the E3 ubiquitin ligase activity of Parkin through its transition from an autoinhibited state to an active conformation (Riley et al., 2013)

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It appears that maintaining adequate blood levels of the vitamin, like through supplementation, does improve birth outcomes ( SUMMARY A vitamin B12 deficiency can cause a range of mild to severe side effects, including anemia, weakness and fatigue, and birth defects in infants

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