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In astudyinvolving rats, BPC-157 was administered in doses of 0, 0.1, 0.25, and 0.5 micrograms/mL over 24 hours. Results showed that the 0.5 microgram/mL dose significantly increased growth hormone expression from day 1 to day 3, while lower doses also had similar effects. The study concluded that BPC-157 supplementation led to increased up-regulation of growth hormone in a dose and time-dependent manner

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Observed adverse events such as myalgia and headaches were classified as mild to moderate and assessed as unrelated to the interventions.20 This means that researchers ultimately determined that the headaches and muscle pain experienced by patients during the studies were not due to urolithin A supplementation