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Cagrilintides gastric effect is inferred with reasonable confidence from receptor pharmacology, animal data, and its gastrointestinal side-effect profile, but published monotherapy trials did not center on validated gastric-emptying measurements (scintigraphy or breath testing) tracked over time

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CHCHD2 stabilizes OPA1, a crucial protein for mitochondrial fusion (174), thereby contributing to mitochondrial integrity

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