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Moreover, due to poor efficacy and adverse reactions, most drugs in this class fail clinical trials [29]
While sustained firing of action potentials or longer lasting depolarization are keys to neuronal BDNF secretion, the subsequent signaling cascades and the molecular machinery triggering and regulating BDNF vesicle exocytosis have just begun to be elucidated

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3), and the backbone of each complex also closely resembled the previously determined active structures of individual AMYRs bound to rat Amy (rAmy) 15 (Fig
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The sources and catalogs of primary antibodies were listed in above Reagents section
