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New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters

M., D'aquino A., and Mondello M

[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Mima K, Sukawa Y, Nishihara R, Qian ZR, Yamauchi M, Inamura K, et al

J Med Chem 42(3):364372

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Administration of GSTP recombinant protein (2 mg/kg, i.p.) to both wild type and Gstp / mice 30 min after CLP surgery significantly alleviated CLP-induced acute lung injury, decreased HMGB1 release and mortality of mice (Figures 1AC)