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The risk-benefit calculation remains unclear

A 2024 review surveyed neurotransmitter-system interactions in this body of work (PMID 38675421), suggesting the compound's effects on central nervous system tissue may share mechanisms with its peripheral activity

For a 90 kg (198 lb) man, thats approximately 2,250 nmol total, which converts to roughly 190210 mcg per dose depending on the exact molecular calculations

Epub 2020 Dec 22

Not all protection strategies work in every situation, so a variety of acyloxyalkyl, amidate and mixed ester/amidate strategies have been developed