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RS, with an incidence of 1:10,00015,000, is the second most common cause of severe intellectual disability in women, and during its developmental regression, a substantial proportion of patients meet the diagnostic criteria for autism spectrum disorder (ASD) [77,78,79,80,81,82,83]
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and decreasing the expression of dynamin-related protein 1 (Drp1) and mitochondrial fission protein 1 (Fis1) [17]
