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NOCA4 attaches to ferritin and is destroyed by ferritin phagocytosis (76), eventually releasing free iron to participate in the Fenton reaction, which generates ROS and increases the accumulation of intracellular lipid peroxides (LPOs) and ferroptosis (77) ( Figure 2 )

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For treatment of confirmed deficiency , NHS protocols typically involve hydroxocobalamin injections: initially 1mg three times a week for two weeks for those without neurological involvement, followed by maintenance injections every 2-3 months
The potential mechanism of the microbiota-gut-bone axis in osteoporosis: a review

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