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Sample size in the hundreds, follow-up of several months, prespecified primary endpoint, independent funding or at least transparent funding disclosure, replication of key findings

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There are compounds currently available on the market that promise various combinations of the benefits mentioned above

Phase Cag introduction Weeks 9-12 Retatrutide 4 mg/week (hold) Cagrilintide 0.25 mg/week Notes Add cagrilintide at the lowest dose