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Mushrooms as possible antioxidant and antimicrobial agents

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Concentrations of 0.05 mM and 0.1 mM markedly reduced the ROS levels

The average levels of Se in white, whole grain

Although it was first identified in gastric juice , today it is synthesized in laboratories for research purposes

It confirmed ferroptosis as the core mechanism in PD pathogenesis synergistically induced by iron overload and inflammation, which activate ferroptosis by disrupting iron metabolism, inhibiting the antioxidant system and exacerbating lipid peroxidation, further causing dopaminergic neuronal damage, -syn aggregation, and PD-characteristic motor/cognitive impairments (186).Treating SH-SY5Y dopamine neurons with rotenone and using RhoNox-1 staining, followed by confocal microscopy observation and flow cytometry analysis, revealed significantly higher intracellular Fe 2+ in the rotenone group, confirming cellular iron overload (187)