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The first step to understanding the molecular nature of GSH movement between the organelles was identification in Arabidopsis of a small family of genes similar to chloroquine-resistance transporter of Plasmodium falciparum (Maughan et al., 2010)
Plasma protein binding also affects drug distribution
Most studies rely on animal models, with a lack of comprehensive clinical trial data in humans
doi: 10.1038/nmeth.3337 30 YoshiharaKShahmoradgoliMMartnezEVegesnaRKimHTorres-GarciaWet al
doi: 10.1016/j.ejphar.2010.02.011
