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Inspect sites regularly for redness, swelling, or other reactions

Common trial endpoints are (1) new gadolinium-enhancing T1-weighted lesions, (2) new or enlarging T2-weighted lesions, (3) annualized relapse rates, and (4) confirmed disability progression for 6 months

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The "Long R3" refers to two key modifications: an arginine substitution at position 3 and a 13-amino acid N-terminal extension

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