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Breaking Plateaus Without Escalating GLP-1 Doses When a patient plateaus on a standard gut hormone peptide, the reflex is often to increase the dosage

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However, long-term safety in humans has not been established , and risks may increase with improper sourcing, excessive dosing, or chronic use

Participants taking the highest dose of orforglipron (36 mg) experienced a mean weight loss of 7.3 kg , or 7.9%, compared with 1.3 kg or 1.6% in the placebo group