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The downstream effects of the two enzymes are opposite: ACE activity leads to vasoconstriction, oxidative stress, inflammation and apoptosis, whereas ACE2 causes vasodilatation, angiogenesis and anti-inflammatory, anti-oxidative and anti-apoptotic effects [1]

Islam T, Manna M, Kaul T, Pandey S, Reddy CS, Reddy MK (2014) Genome-wide dissection of Arabidopsis and rice for the identification and expression analysis of glutathione peroxidases reveals their stress-specific and overlapping response patterns

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32b), which was very different from the majority of the previously reported nanozymes 1,2,3,40