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In 1969, the enzymatic activity of SODs was discovered when a copper protein was identified that could catalytically remove the Pauling free radical, the first experimentally recognized form of superoxide [10,11]

GYY4137 inhibits NF-B p65 activation via protein sulfhydration To evaluate the effect of GYY4137 modification on p65 transcriptional activity, we first examined p65 DNA binding activity in LPS/ATP stimulated macrophages treated with or without GYY4137