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doi: 10.1172/JCI99032

Human clinical data exists as well

The beneficial effects of polyphenols on the state of intestinal epithelium are associated with beneficial effects on the state of TJs and an increase in mucus production, as well as effects on the activity of several protein kinases

It can release paracrine (direct effects on neighboring structures through diffusion) and/or endocrine adipokines, inflammatory factors (both pro- and anti-inflammatory), miRNAs, and other molecules influencing vascular homeostasis

The underlying pathogenic cause of peripheral neuropathy in these individuals is reduced pyruvate flux due to hyperphosphorylation of pyruvate dehydrogenase complex (36

NIDDK, National Institute of Diabetes and Digestive and Kidney Diseases