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The Fibrotic effects of TMAO on Human renal fibroblasts is mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR pathway
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TMAO activates the NLRP3 inflammasome through three distinct signaling mechanisms: mitochondrial dysfunction induced by Rac1-NOX2-dependent ROS production, which causes cytosolic release of oxidized mtDNA
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The Heterogeneity of Cancer Metabolism
