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This represents a shift from a decade ago when hospitalization costs represented the largest component

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Co-treatment with cellular antioxidant agents including EUK-134 (6), resveratrol (84), curcumin (9), CoQ10 (90), dimethyl fumerate (DMF) (95), melatonin (64, 159), and -lipotic acid (160, 161), as well as mitochondrially specific antioxidants including Trolox (14), mitoQ (70), Mito-Tempo (87), and elampimide (13, 87), have been demonstrated to reduce or completely abrogate mitochondrial lesions, including lipid peroxidation, intrinsic apoptosis, and impaired ATP production in both in vitro and in vivo rodent models