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For metabolically stable patients at risk of progression, a very low-protein diet (0.30.4 g/kg/day) supplemented with essential amino acids or ketoacid analogs may be considered under close supervision (276)

Behavioural and Emotional Regulation: Challenging behaviours such as meltdowns, self-injurious behaviour, aggression or extreme rigidity are often the result of unmet communication needs, sensory overload, anxiety, or an inability to regulate overwhelming emotions

Regulatory frameworks across the US FDA, EU, China, and Health Canada continue evolving toward risk-based, lifecycle-oriented approaches for AI-enabled medical devices (European Medicines A gency EMA, 2023

These include: chronic neuroinflammation noise-induced hearing loss is associated with elevated proinflammatory cytokines and microglial activation in the primary AC