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These changes are associated with significant modifications in the gut microbiota, particularly via an increase in Prevotella , a microbial genus often linked to plant-based dietary patterns (107)

Whereas results of some trials are still pending (e.g., NCT03486223), a Phase II trial introducing a thrice-daily application of an orally administered sEH inhibitor in patients with mild to moderate arterial hypertension and pre-diabetes, failed to demonstrate an improvement of insulin sensitivity (NCT00847899)

As a result, there is a substantial reduction in yield

10.1016/j.neuron.2006.03.020 105 Le MeurK.GalanteM.AnguloM

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