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Among these, BBB penetration is the most extensively studied and is considered the most promising strategy because of its minimally invasive nature (17)

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All described studies evaluating small intestinal permeability used a 5 or 6 h urinary collection to assess small intestinal permeability, which may have confounded the results since a large amount of the sugars were probably already localized in the colon by the end of the urine collection (73, 74)

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MtDNA plays an important role in maintaining mitochondrial function