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The apoplastic fraction of AsA is regarded as the determinant of oxidative stress signaling, although its magnitude and duration represent the overall redox status of cell apoplast (Foyer and Noctor, 2003) and nitric oxide (Bethke et al., 2006) reported that redox states of the apoplastic ascorbate levels influence hormonal balance, growth responses, MAPK signaling cascades and antioxidant enzyme activities, while glutathione levels remain unaffected

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We further tested the activity of compound 102 in cellular assays in which GPX4 is in its native form