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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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Disclaimer: The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment

Additionally, semaglutide carries a boxed warning about potential thyroid C-cell tumor risk based on animal studies, though this has not been observed in human trials

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