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Interactions with pre-existing conditions

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Funding This study was supported by the Medical Science Research Program of Hebei Province (20220709), the Government Funded Clinical Medicine Excellent Talent Training Project (ZF2022034), and the Hebei Natural Science Foundation (H2022316005)

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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)