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Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood-brain barrier

This data suggests that clavulanic acid might be a candidate for relieving NP in diabetes mellitus, and its benefits may be attributed to the increased expression of GLT-1 [335]

JR: Writingreview and editing, Writingoriginal draft, Conceptualization

[PubMed: 2284007] 289

doi:10.1016/j.phymed.2018.12.011

Instead, AOD 9604 is used to study downstream metabolic processes, particularly adipose tissue signaling and lipid metabolism, without activating the broader endocrine cascade associated with the GH axis