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Description
The group of Von Zastrow was the first to identify a protein, named GASP for GPCR associated sorting protein, which could actively target DOR to lysosome (Whistler et al., 2002)
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For example, Yin et al

NMDA receptor dysfunction seems implicated in schizophrenia, post-traumatic stress disorder, autoimmune cognitive syndromes, and age-related cognitive decline
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