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Materials and Methods Strains used in this study ZAS163 [syEx1252( gpa6 ::GCaMP3, pha1 ::PHA1)

Manufactured under controlled production standards

Under normal conditions, activated Met is rapidly removed from the cell surface by ubiquitination, and then targets the lysosomal degradation chamber

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162 These metabolic alterations eventually lead to the overproduction of HA and Plasminogen activator inhibitor 1 (PAI-1) and the expansion of Tregs and myeloid-derived suppressor cells (MDSCs) populations

Upon activation of a GPCR, the heterotrimeric G protein dissociates into and subunits, which then modulate the function of a diverse array of effector proteins to simultaneously influence many cellular functions (Latek et al., 2012)