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Some medications can reduce the absorption of vitamin B12 including me dull, tobramycin, gentamicin, and other medications such as tributyl antihistamines

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However, long-term safety data is limited

Antineoplastics that are antimetabolites for the vitamin may induce inadequate utilization of vitamin B12

The authors show that adipose de novo lipogenesis is supported by glucose, and the pentose phosphate pathway provides NADPH, while hepatic lipogenesis mainly uses acetate and lactate, with NADPH generated by folate-mediated serine catabolism