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Available evidence supports the cautious reintroduction of sulfonamide antibiotics via desensitization, which is usually well tolerated and should be considered in those with strong indications for trimethoprim-sulfamethoxazole and a reported sulfonamide allergy

Once generated, the toxic acetaldehyde is quickly converted to less toxic acetate by aldehyde dehydrogenases (ALDHs), and the acetate is broken down into water and CO 2 for easy elimination

Rheumatology (Oxford) 45 , 508521 (2006)

Importantly, DSIP does not appear to cause the hangover effects, cognitive impairment, or next-day sedation commonly seen with traditional hypnotics and sedatives like benzodiazepines or Z-drugs

Haleem Mohammed Dr

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